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Vozza A et al
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Upon sensing environmental stress or cellular damage, the absent in melanoma 2 inflammasome (AIM2) and NLR family pyrin domain-containing 3 (NLRP3) inflammasome assemble and recruit the inflammasome adapter protein apoptosis-associated speck-like protein containing CARD, leading to the activation of pro-inflammatory caspases [137]
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Research shows retatrutide produces glycemic improvements comparable to or exceeding tirzepatide despite the glucagon receptor activation component, suggesting the glucose-lowering effects of GLP-1 and GIP activation offset glucagon's hyperglycemic potential
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